- Grant Adcox, race car driver
- John Ankerberg, author, religious broadcaster
- Kay Arthur, author, teacher and television host
- Lovie Austin, jazz blues pianist, bandleader, and composer
- Howard Baker, former U.S. Senator and White House Chief of Staff
- Hugh Beaumont, actor
- Charles K. Bell, politician
- Jimmy Blanton, bass player
- Rachel Boston, Miss Tennessee Teen USA 1999, actress
- Adarius Bowman, CFL Player
- Tony Brown, NFL player, Tennessee Titans
- Daniel Bullocks, NFL player, Detroit Lions
- Josh Bullocks, NFL player, New Orleans Saints
- Archie Campbell, writer and star of Hee Haw, recording artist
- Dixie Carter, actress
- George S. Clinton, film score composer for the Austin Powers series
- Will Marion Cook, African-American composer
- Charles Coolidge, World War II Medal of Honor recipient
- Bob Corker, former Chattanooga mayor and U.S. Senator
- Bill Dedman, Pulitzer Prize-winning journalist
- Juliette Derricotte, African-American educator and political activist
- Cal Ermer, former MLB manager for the Minnesota Twins
- Lorenzo Kom'boa Ervin, African American writer, activist,and Black anarchist.
- James B. Frazier, Governor of Tennessee, 1903-1905
- Betty Lou Gerson, actress
- Gibby Gilbert, professional golfer
- George Gobel, comedian
- Arthur Golden, author of Memoirs of a Geisha
- Sam Gooden, African-American soul singer with The Impressions.
- Terry Gordy, professional wrestler
- Ray Gordy, professional wrestler for the WWE
- Irvine W. Grote, chemist, inventor of Rolaids
- Ben Haden, minister, author, religious broadcaster
- Lee H. Hamilton (D-IN), United States House of Representatives, 1965-1999
- Dennis Haskins, actor
- Roland Hayes, tenor
- Calvin C. Hernton, African American sociologist, poet and author.
- Rick Honeycutt, L.A. Dodgers pitching coach and former MLB player
- Henry H. Horton, Governor of Tennessee
- Michael Houser, lead guitarist, Widespread Panic
- George Hunter, Coca-Cola Bottling magnate, founder of the Benwood Foundation and the Hunter Museum of American Art
- Samuel L. Jackson, actor
- Leslie Jordan, actor
|
- Estes Kefauver, U.S. Senator
- Venus Lacy, gold medalist in basketball, 1996 Summer Olympics
- Yusef Lateef, saxophonist and music educator
- Cartter Lupton, Coca-Cola Bottling magnate and founder of the Lyndhurst Foundation
- Peyton Manning, NFL player
- Ralphie May, stand-up comedian
- Lurlene McDaniel, popular YA author
- William Gibbs McAdoo, Secretary of the Treasury under Woodrow Wilson
- Ralph McGill, editor of Atlanta Constitution
- Ellis K. Meacham, author
- Jon Meacham, editor of Newsweek magazine
- Olan Mills, Sr., photographer, portrait studio founder
- Jackie Mitchell (baseball player), female pitcher who struck out Babe Ruth while playing for the Lookouts
- Grace Moore, soprano, actress
- Scrappy Moore (football), football coach
- Jim Nabors, actor, singer
- Nevertheless, Christian alternative band
- Adolph S. Ochs, publisher of the Chattanooga Times and New York Times
- Terrell Owens, current NFL player, Dallas Cowboys
- Lori Petty, actress
- Ann Patton, African American recording artist and harpist.
- Ishmael Reed, novelist
- Pat Robertson, founder of the 700 club
- Usher Raymond, rhythm and blues singer
- Terdell Sands, Howard graduate, NFL Player
- M.B. "Bud" Seretean, American businessman, philanthropist
- Tracy Seretean, American filmmaker
- T.G. Sheppard, country music singer
- Danny Shirley, lead singer of Confederate Railroad
- Margaret Sloan-Hunter, Black feminist, lesbian, civil rights advocate, and one of the founding editors of Ms. Magazine.
- Bessie Smith, blues singer
- Kurt Smith, NFL player, San Diego Chargers
- Lewis Smith, actor
- Valaida Snow, African-American jazz trumpet player
- Mary Q. Steele, Newbery Honor-winning children's author
- William O. Steele, Newbery Honor-winning children's author
- Grady Sutton, actor
- Roscoe Tanner, tennis player
- Johnny Taylor, professional basketball player
- Benjamin Thomas, co-founder of the first Coca-Cola Bottling Company
- Ted Turner, founder of CNN
- Roger Alan Wade,singer/songwriter
- Leon "Daddy Wags" Wagner, MLB player for the Los Angeles Angels and the Cleveland Indians, among others
- Reggie White, football player
- Bart Whiteman, writer and critic
|